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Spatial profiling of chromatin accessibility in mouse and human tissues
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Single-cell sequencing presents a tangible way to define cell types and states 7, but the tissue dissociation process leads to the loss of spatial context. Moreover, the method of isolation in single-cell technologies may preferentially select certain cell types or perturb cellular states as a result of the dissociation or other environmental stresses8. Spatial transcriptomics emerged to address these challenges and to transform how we delineate cellular functions and states in the native tissue environment1,2,3,4,5. To investigate the mechanisms underlying the spatial organization of different cell types and functions in the tissue context, it is highly desired to examine not only gene expression but also epigenetic underpinnings such as chromatin accessibility9 in a spatially resolved manner. Spatial epigenetic mapping would help us to uncover the causative relationship that determines what dr
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Gorazd Rosoklija
Antidepressants increase neural progenitor cells in the human hippocampus
Neuropsychopharmacology, 2009
Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) increase neu... more Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) increase neurogenesis in the dentate gyrus (DG) of rodents and nonhuman primates. We determined whether SSRIs or TCAs increase neural progenitor (NPCs) and dividing cells in the human DG in major depressive disorder (MDD).
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Local activation of the complement system in endoneurial microvessels of diabetic neuropathy
Acta Neuropathologica, 2000
Quantitative immunocytochemical analysis of complement proteins (CP) was performed on sural nerve... more Quantitative immunocytochemical analysis of complement proteins (CP) was performed on sural nerve biopsies from 15 patients with diabetic neuropathy (DN) and 18 nondiabetic patients with other forms of chr
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Published in final edited form as: Biol Psychiatry. 2019 Jan 17;85(10):850–862. doi: 10.1016/j.biopsych.2018.12.022
Maura Boldrini
1Department of Psychiatry, New York State Psychiatric Institute, New York, New York; Columbia University, Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York
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Hanga Galfalvy
2Department of Psychiatry, New York State Psychiatric Institute, New York, New York; Department of Biostatistics, New York State Psychiatric Institute, New York
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Andrew J Dwork
3Department of Psychiatry, New York State Psychiatric Institute, New York, New York; Department of Pathology and Cell Biology, New York State Psychiatric Institute, New York, New York; Columbia University, Division of Molecular Imaging and Neuropathology, New York State