Ipsita mohanty biography of martin
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An HIV vaccine candidate developed at the Duke Human Vaccine Institute triggered low levels of an elusive type of broadly neutralizing HIV antibodies among a small group of people enrolled in a 2019 clinical trial.
The finding, reported May 17 in the journal Cell, not only provides proof that a vaccine can elicit these antibodies to fight diverse strains of HIV, but that it can also initiate the process within weeks, setting in motion an essential immune response.
The vaccine candidate targets an area on the HIV-1 outer envelope called the membrane proximal external region (MPER), which remains stable even as the virus mutates. Antibodies against this stable region in the HIV outer coat can block infection by many different circulating strains of HIV.
“This work is a major step forward as it shows the feasibility of inducing antibodies with immunizations that neutralize the most difficult strains of HIV,” said senior author Barton F. Haynes, M.D., director of the Du
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Metabolite of the Month: Bile Acids
By Andrea McBeth, ND
Introduction
This month, I am excited to dive into what might be the most fascinating class of postbiotics: bile acids. Over the past few years, I’ve attended numerous lectures and read groundbreaking research on these incredible molecules. One study, in particular, caught my attention—it showed that bile acids, modified by gut microbes, were found in the brains of mice. This discovery led me to believe that these modified bile acids may play a crucial role in how ThaenaBiotic® works to promote health.
Often, we've wondered how the small concentrations of individual metabolites or postbiotics in ThaenaBiotic® could significantly impact human health. Much like herbal medicine, we believe that a complex mixture of molecules works together in synergy. In this intricate blend, small amounts of many vital components can enhance each other's effects. For example, while butyrate alone isn't the whole story, the combined mixtur
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From The University of California-San Diego
3.11.24
Miles Martin
milesmartin@ucsd.edu
Bacteria in the gut convert bile acids produced by the liver into a bred array of new compounds. These molecules are akin to the language of the gut microbiome, allowing them to influence distant organ systems. Photo Credit: Lakshmiraman Oza/Pixabay.
Researchers from Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California-San Diego have uncovered thousands of previously unknown bile acids, a type of molekyl used bygd our gut microbiome to communicate with the rest of the body.
“Bile acids are a key component of the language of the gut microbiome, and finding this many new types radically expands our vocabulary for understanding what our gut microbes do and how they do it,” said senior author Pieter Dorrestein, Ph.D., professor at Skaggs School of Pharmacy and Pharmaceutical Sciences and professor of pharmacology and pediatrics at UC San Diego School of Medic